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The present invention overcomes the above-mentioned limitations associated with the treatment of actinic keratosis (“AK”) with FDA-approved cryosurgery through the discovery of novel and improved AK treatment regimens comprising lesion-directed therapy, such as cryosurgery, and field-directed therapy, such as imiquimod topical therapy, used in combination to complement one another to treat actinic keratosis.

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In addition there are a number of similar related conditions; psoriatic arthritis, juvenile arthritis, ankylosing spondelytis, Crohn's disease and psoriasis.

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In terms of extended efficacy, imiquimod demonstrates significantly greater sustained clearance rates at 12 months.

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Objective response rate (RR) assessed by an independent review committee was the primary endpoint.

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By “partial clearance”, as used herein, the term means the reduction of clinically visible or palpable AK lesions by at least about 75% in the treatment area as compared with Baseline.

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El encargo está aceptado y Usted verá la notificación en su pantalla y el mensaje del conforme del encargo automaticamente será enviado al email que Usted haya mencionado.

The most important skin diseases on the nose that can require surgical consultation or successfully undergo laser therapy are described below.

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You are prohibited from using, downloading, republishing, selling, duplicating, or "scraping" for commercial or any other purpose whatsoever, the Provider Directory or any of the data listings or other information contained therein, in whole or in part, in any medium whatsoever.

The addition of cyclophosphamide also resulted in more robust IFN-γ responses by tumor-specific cytotoxic T cells and provided protection from tumor rechallenge.

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However, in psoriasis, Stat3 was consistently activated in epidermal keratinocytes, which was assumed to recapitulate persistent wound healing reaction.

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Since the introduction of the liquid nitrogen cryosurgical probe in the 1960's, lesion-directed cryosurgery has become the dominant method for treating actinic keratoses.

Subject age, height, weight, and Baseline lesion count is summarized by mean, standard deviation, median, and range by treatment group.

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