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In this embodiment, the delay in the administration or release of mechanoreceptor stimulator is typically equal to the Tmax of the CNS active agent minus the Tmax of the mechanoreceptor stimulator plus about 5 to about 30 minutes.
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The term "ketone" as used herein is represented by the formula A1C(O)A2, where Al and A2 can be, independently, an alkyl, halogenated alkyl, alkenyl, alkynyl, aryl, heteroaryl, cycloalkyl, cycloalkenyl, heterocycloalkyl, or heterocycloalkenyl group described above.
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It is also understood that there are a number of values disclosed herein, and that each value is also herein disclosed as "about" that particular value in addition to the value itself.
The term "sulfone" as used herein is represented by the farmula A1 S(O)2A2, where Al and Aa can be, independently, an alkyl, halogenated alkyl, alkenyl, alkynyl, aryl, heteroaryl, cycloalkyl, cycloalkenyl, heterocycloalkyl, or heterocycloalkenyl group described above.
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In one embodiment, the CNS active agent administered is in a time-dependent release form, preferably before the vagal neuromodulator's administration in order to ensure that the CNS active agent (already absorbed into the blood from the intestines) will be available for modulation of vagal afferent or efferent receptors while the neuromodulators are active in the stomach.
The materials, compounds, compositions, articles, and methods described herein may be understood more readily by reference to the following detailed description of specific aspects of the disclosed subject matter and the Examples included therein.
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For example, many of the disclosed ionic liquid compositions can be used for therapeutic or nutritional purposes in a subject.
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Materials and Compositions Certain materials, compounds, compositions, and components disclosed herein can be obtained commercially or readily synthesized using techniques generally known to those of skill in the art.
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In this embodiment the CNS agent maybe in an amount that is substantially the same as the conventially accepted effective dosage still have a reduction in at least one side-effect of the CNS.
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